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Brain tumor case revives full-body MRI question: who should get one?

While a recent case has revived interest in full-body MRI scans, medical groups warn healthy adults of the risks of false positives.

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Large white MRI machine with a circular bore and a patient table extended from the opening in a clinical imaging room. It looks ready for a scan, with overhead ceiling lights and neutral walls in the background.

REDWOOD CITY, Calif., July 21 (San Francisco News Online) — A preventive full-body MRI that reportedly found a brain tumor in a former “Bachelor” contestant has put whole-body scans back in the spotlight. But for most healthy adults, the bigger question is not what a scan can find — it is whether the finding changes care enough to justify the tradeoffs.

The Food and Drug Administration says it knows of no scientific evidence showing that whole-body scanning of people without symptoms provides more benefit than harm. The American College of Radiology says there is not enough evidence to recommend total-body screening for people who have no symptoms, risk factors or family history suggesting disease or serious injury. The American College of Preventive Medicine says doctors should not use whole-body scans for early tumor detection in people without symptoms.

What is a full-body MRI?

A full-body MRI is a magnetic imaging test that looks at many parts of the body in one session. Unlike CT scans, MRI does not use ionizing radiation, the American Cancer Society says.

That makes MRI sound safer at first glance, but safety is only one part of the equation. The American Cancer Society says full-body MRI is not part of standard medical care, which is one reason insurers rarely pay for it.

Why are doctors cautious?

The concern is that a scan can turn up something that looks alarming but is not actually dangerous. The American Cancer Society says these scans can show “spots” or “shadows” that may be normal variations in the body. Those unexpected findings can lead to more tests, biopsies, procedures and anxiety.

That is often called a false positive, meaning the scan suggests a problem that later turns out not to be cancer or another serious disease. Another issue is overdiagnosis, which Cleveland Clinic defines as finding a condition that would not have gone on to cause major symptoms or death.

Cleveland Clinic also says full-body MRI can miss problems, creating false reassurance for someone who leaves thinking everything is fine.

In a JAMA editorial reported by ABC News, Matthew Davenport of the University of Michigan and Dr. Scott Reeder said no major medical group recommends whole-body MRI for the general population because the benefits remain unproven. Davenport said the harms can come from invasive testing, surgery or follow-up of findings of uncertain benefit.

What does this mean for a healthy person?

For someone with no symptoms and no known high-risk condition, the current guidance from major medical groups points in the same direction: routine full-body screening is not recommended.

The U.S. Preventive Services Task Force gives pancreatic cancer screening in asymptomatic adults who are not known to be at high risk a D rating, meaning the harms outweigh the benefits. That does not mean no one should ever get imaging; it means broad screening in people who feel well has not shown clear benefit.

That is why the recent local warning from UCSF matters. UCSF radiology researcher Dr. Rebecca Smith-Bindman said there is “not a stitch of evidence” that the scan helps people live longer or better, and she warned that false positives can lead to more testing.

So why do the scans still attract attention?

A dramatic story about a tumor found before symptoms can make full-body MRI sound like a lifesaver. But major medical groups say one success story is not the same as proof that routine screening helps healthy people overall.

For San Francisco readers, the takeaway is simple: a preventive scan may sound reassuring, but federal regulators and major specialty groups say the evidence still does not support using whole-body MRI as a routine screening test for people without symptoms or specific risk factors.

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Thurman Boiles

Raised in Moraga, California, Thurman Boiles is the Sacramento reporter for Times Media Service. Boiles covers local news in Sacramento and crime and justice across California, including public safety, breaking events and the laws and regulations that shape them. Boiles holds a master's degree in communication with a focus on journalism.

Write to Thurman